abstract：:Increased neurogenesis by promoting proliferation of neural precursor cells in the adult dentate gyrus might be beneficial for the treatment of psychiatric disorders. Results demonstrate that bFGF is necessary for the proliferation of neural precursor cells and that the glycogen synthase kinase-3β (GSK-3β) and β-caten...

journal_title：Brain research

authors： Boku S,Nakagawa S,Toda H,Kato A,Takamura N,Omiya Y,Inoue T,Koyama T

更新日期：2013-01-25 00:00:00

abstract：:Source memory for the speaker's voice (male or female) was investigated when semantic knowledge (gender stereotypes) could and could not inform the episodic source judgment while event-related potentials (ERPs) were recorded. Source accuracy was greater and response times were faster when stereotypes could predict the...

journal_title：Brain research

authors： Leynes PA,Crawford JT,Radebaugh AM,Taranto E

更新日期：2013-01-23 00:00:00

abstract：:Despite significant advancements in the understanding of the pathophysiological mechanisms of subarachnoid hemorrhage (SAH), little is known about the emotional consequences. The primary goal of this study was to describe the locomotor and behavioral patterns in rats following both a single-injection and double-inject...

journal_title：Brain research

authors： Boyko M,Azab AN,Kuts R,Gruenbaum BF,Gruenbaum SE,Melamed I,Brotfain E,Shapira Y,Cesnulis E,Zlotnik A

更新日期：2013-01-23 00:00:00

abstract：:Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe the therapeutic time window of honokiol microemulsion on cerebral ischemia-reperfusion injury to support its potential for fut...

journal_title：Brain research

authors： Hu Z,Bian X,Liu X,Zhu Y,Zhang X,Chen S,Wang K,Wang Y

更新日期：2013-01-23 00:00:00

abstract：:Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...

journal_title：Brain research

authors： Kishimoto Y,Higashihara E,Fukuta A,Nagao A,Kirino Y

更新日期：2013-01-23 00:00:00

abstract：:The core neuropsychological processes underlying post-traumatic stress disorder (PTSD) have yet to be elucidated, and the association between anatomical and functional deficits in PTSD remains largely unknown. The aim of our study was to investigate the alterations in cortical thickness and amplitude of low-frequency ...

journal_title：Brain research

authors： Bing X,Ming-Guo Q,Ye Z,Jing-Na Z,Min L,Han C,Yu Z,Jia-Jia Z,Jian W,Wei C,Han-Jian D,Shao-Xiang Z

更新日期：2013-01-15 00:00:00

abstract：:The present study examines the brain-level representation and composition of meaning in scalar quantifiers (e.g., some), which have both a semantic meaning (at least one) and a pragmatic meaning (not all). We adopted a picture-sentence verification design to examine event-related potential (ERP) effects of reading inf...

journal_title：Brain research

authors： Politzer-Ahles S,Fiorentino R,Jiang X,Zhou X

更新日期：2013-01-15 00:00:00

abstract：:Microtubule-stabilizing drugs are useful in cancer therapy and show promise for treatment of neurodegenerative diseases. An overlapping binding site between tau and taxoid site drugs has led to a number of research papers investigating the competitive interaction between these drugs and the microtubule. This has impli...

journal_title：Brain research

authors： Das V,Miller JH

更新日期：2012-12-13 00:00:00

abstract：:The current study investigated the time course of the implicit processing of erotic stimuli using event-related potentials (ERPs). ERPs elicited by erotic pictures were compared with those by three other types of pictures: non-erotic positive, negative, and neutral pictures. We observed that erotic pictures evoked enh...

journal_title：Brain research

authors： Feng C,Wang L,Wang N,Gu R,Luo YJ

更新日期：2012-12-13 00:00:00

abstract：:Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...

journal_title：Brain research

authors： Kuo MC,Dringenberg HC

更新日期：2012-12-07 00:00:00

abstract：:Electrical synaptic transmission via gap junctions has become an accepted feature of neuronal communication in the mammalian brain, and occurs often between dendrites of interneurons in major brain structures, including the hippocampus. Electrical and dye-coupling has also been reported to occur between pyramidal cell...

journal_title：Brain research

authors： Nagy JI

更新日期：2012-12-03 00:00:00

abstract：:Glial cells play a crucial role in the pathomechanism of perinatal hypoxic-ischemic brain injury (HI) and are involved in the maintenance of a chronic state of inflammation that causes delayed neuronal damage. Activation of astrocytes is one factor prolonging brain damage and contributing to the formation of a glial s...

journal_title：Brain research

authors： Wasielewski B,Jensen A,Roth-Härer A,Dermietzel R,Meier C

更新日期：2012-12-03 00:00:00

abstract：:In the adult brain, γ-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervica...

journal_title：Brain research

authors： Kosaka Y,Kin H,Tatetsu M,Uema I,Takayama C

更新日期：2012-11-27 00:00:00

abstract：:Dopaminergic and glutamatergic afferents simultaneously innervate median spiny neurons (MSNs) and interact to mediate basal ganglia functions. However, the association between dopaminergic and glutamatergic axons is not clear. In the present study, nigrostriatal, corticostriatal, and thalamostriatal axons were anterog...

journal_title：Brain research

authors： Xu C,Zhao J,Liu Y,Zeng X,Jia Y,Wang Y,Jiang X,Xu Q

更新日期：2012-11-27 00:00:00

abstract：:Tinnitus, the perception of a phantom sound, is a common consequence of damage to the auditory periphery. A major goal of tinnitus research is to find the loci of the neural changes that underlie the disorder. Crucial to this endeavor has been the development of an animal behavioral model of tinnitus, so that neural c...

journal_title：Brain research

authors： Baizer JS,Manohar S,Paolone NA,Weinstock N,Salvi RJ

更新日期：2012-11-16 00:00:00

abstract：:Hyperacusis, a marked intolerance to normal environmental sound, is a common symptom in patients with tinnitus, Williams syndrome, autism, and other neurologic diseases. It has been suggested that an imbalance of excitation and inhibition in the central auditory system (CAS) may play an important role in hyperacusis. ...

journal_title：Brain research

authors： Sun W,Deng A,Jayaram A,Gibson B

更新日期：2012-11-16 00:00:00

abstract：:Reactive oxygen species (ROS) and intrinsic antioxidant defense systems play an important role in both physiological cell signaling processes and many pathological states, including neurodegenerative disorders and oxygen-toxicity. Here we report that short exposures to non-physiologic oxygen levels change the balance ...

journal_title：Brain research

authors： Bendix I,Weichelt U,Strasser K,Serdar M,Endesfelder S,von Haefen C,Heumann R,Ehrkamp A,Felderhoff-Mueser U,Sifringer M

更新日期：2012-11-12 00:00:00

abstract：:Rhyme processing is reflected in the electrophysiological signals of the brain as a negative deflection for non-rhyming as compared to rhyming stimuli around 450 ms after stimulus onset. Studies have shown that this N450 component is not solely sensitive to rhyme but also responds to other types of phonological overla...

journal_title：Brain research

authors： Wagensveld B,Segers E,Alphen Pv,Hagoort P,Verhoeven L

更新日期：2012-11-05 00:00:00

abstract：:The objective of the study was to investigate creativity in relation to brain function by assessing creative thinking in various neurological populations. Several measures were employed to assess different facets of creative thinking in clinical groups with frontal lobe, basal ganglia or parietal-temporal lesions rela...

journal_title：Brain research

authors： Abraham A,Beudt S,Ott DV,Yves von Cramon D

更新日期：2012-10-30 00:00:00

abstract：:Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...

journal_title：Brain research

authors： Xie R,Li X,Ling Y,Shen C,Wu X,Xu W,Gao X

更新日期：2012-10-30 00:00:00

abstract：:This review examines vestibular compensation and vestibular rehabilitation from a unified translational research perspective. Laboratory studies illustrate neurobiological principles of vestibular compensation at the molecular, cellular and systems levels in animal models that inform vestibular rehabilitation practice...

journal_title：Brain research

authors： Balaban CD,Hoffer ME,Gottshall KR

更新日期：2012-10-30 00:00:00

abstract：:The present study aimed to evaluate the therapeutic potential of apocynin, an NADPH oxidase assembly inhibitor, on traumatic brain injury. Rat traumatic brain injury (TBI) was performed using a weight drop model. Apocynin (100mg/kg) was injected into the intraperitoneal space 15 min before TBI. Reactive oxygen species...

journal_title：Brain research

authors： Choi BY,Jang BG,Kim JH,Lee BE,Sohn M,Song HK,Suh SW

更新日期：2012-10-24 00:00:00

abstract：:The central nervous system (CNS) in adult mammals loses the ability to regenerate after injury. Although electrical stimulation (ES) has been shown to promote neural regeneration, the underlying mechanisms by which ES enhances CNS regeneration remain elusive. The aim of the present study was to investigate the effect ...

journal_title：Brain research

authors： Ou YT,Lu MS,Chiao CC

更新日期：2012-10-22 00:00:00

abstract：:The globus pallidus plays a critical role in movement regulation. Morphological studies have shown that group I mGluRs including mGluR1 and mGluR5 are expressed in the globus pallidus. Up to now, little is known about the in vivo electrophysiological effects of group I mGluRs on the pallidal neurons. The present study...

journal_title：Brain research

authors： Sun XR,Chen L,Chen WF,Yung WH

更新日期：2012-10-05 00:00:00

abstract：:Humans share the common intuition of a self that has access to an inner 'theater of mind' (Baars, 2003). The problem is how this internal theater is formed. Moving from Cook's view (Cook, 2008), we propose that the 'sentience' present in single excitable cells is integrated into units of neurons and glial cells transi...

journal_title：Brain research

authors： Agnati LF,Guidolin D,Cortelli P,Genedani S,Cela-Conde C,Fuxe K

更新日期：2012-10-02 00:00:00

abstract：:Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuronal synaptic functions in physiological and pathological conditions. Many studies, over the past years, have shown that it is actively involved in PD pathophysiology. Alpha-synuclein is integrated in a complex network o...

journal_title：Brain research

authors： Bellucci A,Zaltieri M,Navarria L,Grigoletto J,Missale C,Spano P

更新日期：2012-10-02 00:00:00

abstract：:Visual search is characterized as efficient (RT independent of distractor number) or inefficient (RT increasing with distractor number). Our goal was to determine if any brain regions are differentially activated by the attentional demands of these two search modes. We used fMRI to examine activation patterns during s...

journal_title：Brain research

authors： Kim KK,Eliassen JC,Lee SK,Kang E

更新日期：2012-09-26 00:00:00

abstract：:This study examines the preventive and therapeutic effects of curcumin on brain edema after hypoxic-ischemic brain damage (HIBD) in a rat model. Male Sprague-Dawley rats were divided into four groups: a sham group (SH), a hypoxic-ischemic group (HI) without drug treatment, a hypoxic-ischemic group (CU) with curcumin i...

journal_title：Brain research

authors： Yu L,Yi J,Ye G,Zheng Y,Song Z,Yang Y,Song Y,Wang Z,Bao Q

更新日期：2012-09-26 00:00:00

abstract：:We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...

journal_title：Brain research

authors： Huang HW,Federmeier KD

更新日期：2012-09-26 00:00:00

abstract：:Prenatal exposure to chlorpyrifos (CPF) leads to cognitive impairments in adulthood. The cytoarchitectural basis is unclear. In the present study, we assessed the effects of prenatal CPF exposure on T-maze delayed alternation task and the win-shift/lose-shift responses associated with the morphology of the dorsal hipp...

journal_title：Brain research

authors： Chen XP,Chen WZ,Wang FS,Liu JX

更新日期：2012-09-20 00:00:00

abstract：:We have recently reported spinal blood flow-metabolism uncoupling in an amyotrophic lateral sclerosis (ALS) animal model using Cu/Zn-superoxide dismutase 1 (SOD1)-transgenic (Tg) mice, suggesting a relative hypoxia in the spinal cord. However, the hypoxic stress sensor pathway has not been well studied in ALS. Here, w...

journal_title：Brain research

authors： Sato K,Morimoto N,Kurata T,Mimoto T,Miyazaki K,Ikeda Y,Abe K

更新日期：2012-09-14 00:00:00

abstract：:The prognosis of patients with malignant glioma remains extremely poor despite surgery and improvements in radio- and chemo-therapies. We recently showed that marrow-isolated adult mutilineage inducible (MIAMI) cells, a subpopulation of human mesenchymal stromal cells (MSCs), can serve as cellular carriers of drug-loa...

journal_title：Brain research

authors： Roger M,Clavreul A,Sindji L,Chassevent A,Schiller PC,Montero-Menei CN,Menei P

更新日期：2012-09-14 00:00:00

abstract：:We have found that daily subcutaneous injection with a maximum tolerated dose (MTD) of the mGluR2/3 agonist LY379268 (20mg/kg) beginning at 4 weeks dramatically improves the phenotype in R6/2 mice. For example, we observed normalization of motor function in distance traveled, speed, the infrequency of pauses, and the ...

journal_title：Brain research

authors： Reiner A,Wang HB,Del Mar N,Sakata K,Yoo W,Deng YP

更新日期：2012-09-14 00:00:00

abstract：:Previous studies showed the role of basolateral amygdala (BLA) in cannabinoid-induced antinociception. Furthermore, the nucleus accumbens (NAc) plays an important role in mediating the suppression of pain in animal models. The present study extended the role of dopamine receptors within the NAc in antinociceptive effe...

journal_title：Brain research

authors： Haghparast A,Ghalandari-Shamami M,Hassanpour-Ezatti M

更新日期：2012-08-30 00:00:00

abstract：:Transient global ischemia induces selective, delayed neuronal death of pyramidal neurons in the hippocampal CA1. Whereas long term treatment of middle-aged female rats with estradiol at physiological doses ameliorates neuronal death, the signaling pathways that mediate the neuroprotection are, as yet, unknown. Protein...

journal_title：Brain research

authors： De Butte-Smith M,Zukin RS,Etgen AM

更新日期：2012-08-30 00:00:00

abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...

journal_title：Brain research

authors： Xie T,Wang WP,Jia LJ,Mao ZF,Qu ZZ,Luan SQ,Kan MC

更新日期：2012-08-27 00:00:00

abstract：:Ischemic insults affecting the internal capsule result in sensory-motor disabilities which adversely affect the patient's life. Cerebral endothelial cells have been reported to exert a protective effect against brain damage, so the transplantation of healthy endothelial cells might have a beneficial effect on the outc...

journal_title：Brain research

authors： Puentes S,Kurachi M,Shibasaki K,Naruse M,Yoshimoto Y,Mikuni M,Imai H,Ishizaki Y

更新日期：2012-08-21 00:00:00

abstract：:Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences ...

journal_title：Brain research

authors： Pang EW,MacDonald MJ

更新日期：2012-07-27 00:00:00

abstract：:During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...

journal_title：Brain research

authors： Rosario ER,Carroll JC,Pike CJ

更新日期：2012-07-23 00:00:00

abstract：:The effects of duloxetine were examined on cloned Kv4.3 channels stably expressed in CHO cells using the whole-cell patch-clamp technique. Duloxetine decreased the peak amplitude of Kv4.3 currents with an acceleration of the decay rate of current inactivation in a concentration-dependent manner. The IC(50) values requ...

journal_title：Brain research

authors： Choi JS,Hahn SJ

更新日期：2012-07-23 00:00:00